Fig. 6: Analysis of patterns of gene variants at EoT.

a,b, Acquired/lost gene alteration from baseline to EoT by comparison of the change in gene amplification status (a) and by comparison of the change of SNV/Indel status (b). c, SNVs/Indels and amplifications from EoT samples. ^aTop ten acquired/loss of amplification from baseline to EoT, including both arms, ordered by P value. The McNemar test was used to compare change in gene amplification status from baseline to EoT regardless of amplification type. Shown is high-frequency amplification at either baseline or EoT in at least five patients among whom HER2 was the only significant amplification change (P = 0.0064). Multiple testing correction was not performed. ^bTop ten acquired/loss of SNVs/Indels from baseline to EoT, including both arms, ordered by P value. The McNemar test was used to compare change in SNV/Indel status from baseline to EoT regardless of function. Shown are high-frequency SNVs/Indels at either baseline or EoT in at least five patients. There were no significant SNVs/Indels. Multiple testing correction was not performed. ^cThe order of data is based on an algorithm aimed at determination of mutual exclusivity. The heatmap shows potential acquired SNVs/Indels detected only at EoT, regardless of function. C1D1, cycle 1, day 1.