Table 1 Study population
From: AI-based differential diagnosis of dementia etiologies on multimodal data
Dataset (group) | Age (y), mean ± s.d. | Male, n (%) | Education (y), mean ± s.d. | Race (White, Black, Asian, American Indian, Pacific, multirace), n | CDR, mean ± s.d. |
|---|---|---|---|---|---|
NACC | |||||
NC [n = 17,242] | 71.25 ± 11.16 | 6,009, 34.85% | 15.83 ± 2.98^ | (13,266, 2541, 528, 109, 10, 575)^ | 0.05 ± 0.15 |
MCI [n = 7,582] | 73.72 ± 9.81 | 3,615, 47.68% | 15.16 ± 3.45^ | (5,708, 1185, 231, 53, 5, 276)^ | 0.45 ± 0.18 |
AD [n = 16,131] | 76.0 ± 10.31 | 7,234, 44.85% | 14.52 ± 3.74^ | (13,161, 1702, 354, 92, 10, 458)^ | 1.2 ± 0.73 |
LBD [n = 1,913] | 75.01 ± 8.55 | 1,365, 71.35% | 15.12 ± 3.63^ | (1,659, 128, 39, 17, 0, 37)^ | 1.29 ± 0.78 |
VD [n = 1,919] | 80.32 ± 8.76 | 947, 49.35% | 14.15 ± 4.22^ | (1,394, 332, 67, 2, 1, 68)^ | 1.22 ± 0.74 |
PRD [n = 114] | 60.07 ± 10.36 | 62, 54.39% | 14.8 ± 3.33^ | (93, 5, 5, 0, 1, 1)^ | 1.95 ± 0.95 |
FTD [n = 2,898] | 65.86 ± 9.36 | 1,603, 55.31% | 15.45 ± 3.09^ | (2,664, 69, 73, 4, 5, 39)^ | 1.2 ± 0.83 |
NPH [n = 138] | 79.1 ± 9.24 | 69, 50.0% | 15.0 ± 3.28^ | (119, 10, 4, 0, 0, 4)^ | 1.18 ± 0.71 |
SEF [n = 808] | 76.3 ± 11.15 | 413, 51.11% | 14.6 ± 3.77^ | (646, 95, 15, 5, 2, 31)^ | 1.11 ± 0.7 |
PSY [n = 2,700] | 73.74 ± 10.78 | 1,102, 40.81% | 14.13 ± 4.12^ | (2,163, 238, 59, 14, 5, 87)^ | 1.1 ± 0.64 |
TBI [n = 265] | 72.87 ± 11.23 | 192, 72.45% | 14.42 ± 4.13^ | (212, 27, 3, 2, 1, 11)^ | 1.11 ± 0.69 |
ODE [n = 1,234] | 72.94 ± 12.14 | 654, 53.0% | 14.5 ± 3.78^ | (1,046, 93, 28, 5, 4, 36)^ | 1.2 ± 0.76 |
P value | < 1.0 × 10−200 | <1.0 × 10−200 | < 1.0 × 10−200 | 8.341 × 10−145 | <1.0 × 10−200 |
NIFD | |||||
NC [n = 124] | 63.21 ± 7.27 | 56, 45.16% | 17.48 ± 1.87^ | (89, 0, 0, 0, 0, 3)^ | 0.03 ± 0.12^ |
FTD [n = 129] | 63.66 ± 7.33 | 75, 58.14% | 16.18 ± 3.29^ | (109, 1, 1, 0, 0, 4)^ | 0.82 ± 0.54^ |
P value | 6.266 × 10−1 | 5.246 × 10−2 | 2.606 × 10−4 | 6.531 × 10−1 | 4.333 × 10−28 |
PPMI | |||||
NC [n = 171] | 62.74 ± 10.12 | 109, 63.74% | 15.82 ± 2.93 | (163, 3, 2, 0, 0, 1)^ | NA |
MCI [n = 27] | 68.04 ± 7.32 | 22, 81.48% | 15.52 ± 3.08 | (24, 1, 1, 0, 0, 1) | NA |
P value | 1.006 × 10−2 | 1.115 × 10−1 | 6.194 × 10−1 | 2.910 × 10−1 | NA |
AIBL | |||||
NC [n = 480] | 72.45 ± 6.22 | 203, 42.29% | NA | NA | 0.03 ± 0.12 |
MCI [n = 102] | 74.73 ± 7.11 | 53, 51.96% | NA | NA | 0.47 ± 0.14 |
AD [n = 79] | 73.34 ± 7.77 | 33, 41.77% | NA | NA | 0.93 ± 0.54 |
P value | 5.521 × 10−3 | 1.887 × 10−1 | NA | NA | 4.542 × 10−158 |
OASIS | |||||
NC [n = 424] | 71.34 ± 9.43 | 164, 38.68% | 15.79 ± 2.62^ | (53, 18, 1, 0, 0, 0)^ | 0.0 ± 0.02 |
MCI [n = 27] | 75.04 ± 7.25 | 14, 51.85% | 15.19 ± 2.76 | (4, 1, 0, 0, 0, 0)^ | 0.52 ± 0.09 |
AD [n = 32] | 77.44 ± 7.42 | 20, 62.5% | 15.19 ± 2.8 | (8, 1, 0, 0, 0, 0)^ | 0.86 ± 0.44 |
LBD [n = 4] | 74.75 ± 5.67 | 4, 100.0% | 16.0 ± 2.83 | NA | 1.0 ± 0.0 |
FTD [n = 4] | 64.25 ± 8.61 | 3, 75.0% | 16.5 ± 2.96 | (4, 0, 0, 0, 0, 0) | 1.25 ± 0.75 |
P value | 7.789 × 10−4 | 3.239 × 10−3 | 5.507 × 10−1 | 8.735 × 10−1 | 2.855 × 10−169 |
LBDSU | |||||
NC [n = 134] | 68.77 ± 7.62 | 61, 45.52% | 17.27 ± 2.47^ | NA | NA |
MCI [n = 35] | 70.16 ± 8.41 | 26, 74.29% | 16.6 ± 2.58 | NA | NA |
LBD [n = 13] | 73.42 ± 7.81 | 8, 61.54% | 16.77 ± 2.15 | NA | NA |
P value | 1.033 × 10−1 | 7.863 × 10−3 | 3.243 × 10−1 | NA | NA |
4RTNI | |||||
NC [n = 12] | 68.08 ± 4.92 | 5, 41.67% | 15.45 ± 2.57^ | (12, 0, 0, 0, 0, 0) | 0.0 ± 0.0 |
MCI [n = 31] | 67.61 ± 7.0 | 11, 35.48% | 16.68 ± 4.02 | (25, 1, 2, 0, 1, 1)^ | 0.55 ± 0.15 |
FTD [n = 37] | 69.14 ± 7.43 | 20, 54.05% | 16.46 ± 4.21 | (31, 1, 0, 0, 1, 2)^ | 1.27 ± 0.55 |
P value | 6.691 × 10−1 | 2.992 × 10−1 | 6.843 × 10−1 | 7.620 × 10−1 | 5.700 × 10−16 |
ADNI | |||||
NC [n = 868] | 72.7 ± 6.57 | 383, 44.12% | 16.51 ± 2.52 | (730, 92, 28, 2, 0, 12)^ | 0.0 ± 0.04^ |
MCI [n = 1119] | 72.77 ± 7.65 | 648, 57.91% | 15.97 ± 2.75 | (1,023, 56, 17, 2, 2, 13)^ | 0.5 ± 0.06 |
AD [n = 417] | 74.99 ± 7.78 | 232, 55.64% | 15.25 ± 2.92 | (383, 20, 10, 0, 0, 4) | 0.77 ± 0.27 |
P value | 8.911 × 10−8 | 3.090 × 10-09 | 2.869 × 10−14 | 2.828 × 10−5 | <1.0 × 10−200 |
FHS | * | ||||
NC [n = 394] | 74.9 ± 10.22^ | 206, 52.28% | NA | (394, 0, 0, 0, 0, 0) | 0.0 ± 0.0 |
MCI [n = 434] | 79.92 ± 8.8^ | 203, 46.77% | NA | (434, 0, 0, 0, 0, 0) | 0.49 ± 0.07 |
AD [n = 687] | 82.99 ± 7.87^ | 211, 30.71% | NA | (687, 0, 0, 0, 0, 0) | 2.04 ± 0.88 |
LBD [n = 73] | 79.34 ± 9.37^ | 46, 63.01% | NA | (73, 0, 0, 0, 0, 0) | 1.84 ± 0.84 |
VD [n = 113] | 81.74 ± 7.3^ | 48, 42.48% | NA | (113, 0, 0, 0, 0, 0) | 1.85 ± 0.8 |
FTD [n = 8] | 85.67 ± 5.91^ | 4, 50.0% | NA | (8, 0, 0, 0, 0, 0) | 2.0 ± 0.87 |
P value | 1.316 × 10−31 | 7.905 × 10−14 | NA | 1.0 | <1.0 × 10−200 |
