Extended Data Fig. 9: Kinetics of vaccine-specific IgG ASC responses in the subject who donated two sequential BM aspirates (at 28 and 33 months after the first SARS-CoV-2 vaccine). | Nature Medicine

Extended Data Fig. 9: Kinetics of vaccine-specific IgG ASC responses in the subject who donated two sequential BM aspirates (at 28 and 33 months after the first SARS-CoV-2 vaccine).

From: SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination

Extended Data Fig. 9: Kinetics of vaccine-specific IgG ASC responses in the subject who donated two sequential BM aspirates (at 28 and 33 months after the first SARS-CoV-2 vaccine).

(a) ELISpot scanned images. The numbers of input ASC incubated were ~3.04 K, ~1.27 K, and ~0.88 K (28 m, total), ~15.20 K, ~7.61 K, and ~2.65 K (28 m, vaccine-specific); and ~1.56 K, ~1.02 K, and ~0.75 K (33 m, total), and ~18.67 K, ~7.12 K, and ~2.98 K (33 m, vaccine-specific), for PopA, PopB, and PopD, respectively. (b) Vaccine-specific IgG ASC response kinetics. ~: counts provided by the sorters; K: 1,000; LLPC: long-lived plasma cell (box); Flu: influenza; Tet: tetanus; m: month. For details of the subject, see Table 1.

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