Fig. 3: Brain injury biomarkers and neuroimaging.
a, Brain injury markers (in pg ml−1) by diagnostic group. Lower limit of quantification (dashed line) if included in scale. Normative values from n = 60 healthy controls. *P < 0.05, **P < 0.01, ***P < 0.001; NS, nonsignificant, unadjusted two-sided Mann–Whitney U. b, Brain regions represented by the IDPs utilized in analyses. These regions are parcellated as per the Desikan-Killiany cortical atlas. For each region and regions combined, IDP composites for thickness and volume were utilized. aIDP composites that have significant correlations with overall cognition (Supplementary Table 2). Created using Matlab and BrainNet Viewer54. c, Scatter plots for IDP composite z-scores against GDfE in the overall cohort, using Pearson’s correlation. The black line indicates the line of best fit (least squares method) and gray error band indicates the 95% CI. Significance persisting after adjusted for multiple comparisons based on the FDR approach (adjusted for n = 14 for each IDP composite test). Center line, median; box limits, upper and lower quartiles; whiskers, 1.5× IQR. ACC, anterior cingulate cortex; ERC, entorhinal cortex; UCH-L1, ubiquitin carboxy-terminal hydrolase L1.
