Fig. 2: CSF YWHAG:NPTX2 versus established neurodegeneration AD biomarkers. | Nature Medicine

Fig. 2: CSF YWHAG:NPTX2 versus established neurodegeneration AD biomarkers.

From: A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease

Fig. 2

a, Levels of CSF NfL, GAP-43, Ng and YWHAG.1:NPTX2 between AD and healthy and A+T1+ and A–T1− in the Knight-ADRC and ADNI cohorts are shown. ***P < 0.001 based on a standard two-sided t-test. The box bounds show the Q1, median and Q3; the whiskers show the Q1 − 1.5× the IQR and Q3 + 1.5× the IQR. b, Linear correlation and P value between CSF YWHAG.1:NPTX2 and CSF NfL in the Knight-ADRC and ADNI cohorts. The colors indicate the CI stage as shown in Fig. 1e. c, As in b but for CSF GAP-43. d, As in b but for CSF Ng. e, r2 results from linear models regressing CI against covariates displayed on the x axis in the Knight-ADRC and ADNI cohorts (n = 1,472). The bars and error bars represent bootstrapped (n = 1,000) means and 95% confidence intervals. Two-sided P values were calculated using the empirical distribution of the bootstrapped test statistic. The difference in r2 values between the full model and the model with NfL, GAP-43 and Ng is shown. ***P < 0.001.

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