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Cancer therapy

A new paradigm for immunotherapy in glioblastoma

A detailed case report shows that neoadjuvant combination immunotherapy can activate antitumor immunity and drive clinical benefit in newly diagnosed glioblastoma, revealing avenues for further research that could shift the treatment landscape to improve survival.

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Fig. 1: Neoadjuvant immunotherapy window of opportunity in glioblastoma.

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Correspondence to Gelareh Zadeh.

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Ellenbogen, Y., Zadeh, G. A new paradigm for immunotherapy in glioblastoma. Nat Med 31, 1404–1405 (2025). https://doi.org/10.1038/s41591-025-03607-9

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