Extended Data Fig. 2: Plasma p-tau217 (Lumipulse) and the effect of demographic characteristics and comorbidities. | Nature Medicine

Extended Data Fig. 2: Plasma p-tau217 (Lumipulse) and the effect of demographic characteristics and comorbidities.

From: Plasma phospho-tau217 for Alzheimer’s disease diagnosis in primary and secondary care using a fully automated platform

Extended Data Fig. 2: Plasma p-tau217 (Lumipulse) and the effect of demographic characteristics and comorbidities.

Boxplots of plasma p-tau217 (Lumipulse) concentrations stratified by AD status and the following variables: (a) sex, (b) APOE ε4 carriership, (c) education, (d), chronic kidney disease, (e) presence of diabetes, and (f) age. The analyses were performed pooling the data of the five cohorts (n = 1767). Dashed lines represent the single cutoff at 90% specificity established in the Malmö secondary care cohort. The dots represent individual participants. The central band of the boxplot represents the group median, the box limits correspond to the first and third quartiles, and the whiskers represent the minimum/maximum value or the 1.5 interquartile range (IQR) from the box, whichever is smaller. AD status was defined as CSF Aβ42/p-tau181 < 11.94 or positive amyloid PET visual read for those who did not undergo lumbar puncture. Group mean levels were compared with Student’s t-test. Abbreviations: AD, Alzheimer’s disease; CKD, chronic kidney disease; IQR, interquartile range.

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