Extended Data Table 1 Analysis of main and interaction effects using the mixed-model repeated measures analysis (MMRM) for PHQ-9 score at week 6, using the Health information arm as the control

From: Cognitive behavioral therapy skills via a smartphone app for subthreshold depression among adults in the community: the RESiLIENT randomized controlled trial

  1. The least squares mean changes and their differences of the PHQ-9 scores were estimated with the mixed-effects models for repeated-measures (MMRM). The regression models included fixed effects of treatment, visit (as categorical), and treatment-by-visit interactions, adjusted for baseline PHQ-9 scores, employment status, age and gender. The interaction P-values are calculated from the MMRM models involving interaction terms of the corresponding treatments. P-values are two-sided and no adjustments are made for multiple comparisons.
  2. † Minus value indicates depression reduction. () indicates 95% confidence intervals.
  3. ‡ Effect sizes (standardised mean differences) were calculated using the observed week 6 SD for group differences.
  4. * See Fig. 1 for the designs of Trials 1 through 4.
  5. ** Participants working on a three-shift schedule were excluded in the primary and its sensitivity analyses for Trial 4.
  6. AT: Assertion training, BA: Behavioural activation, BI: Behaviour therapy for insomnia, CR: Cognitive restructuring, PHQ-9: Patient Health Questionnaire-9, PS: Problem solving.
Back to article page