Extended Data Fig. 6: Relative CMV seropositivity across UKB recruitment centres and association with age at diagnosis of primary.

(a) Relative depletion of CMV+ individuals in MM cohort versus UKB data according to recruitment centre (n = 150): all ORs and P values were obtained from a two-sided Fisher’s exact test. (b) Age of diagnosis of primary cutaneous melanoma by CMV serotype and BRAF status (CMV serology determined at onset of systemic treatment for metastatic disease), (n = 204, PMutant = 0.25, PWild-type = 0.0019, two-sided Wilcoxon rank sum test; lower and upper box hinges represent the 25th to 75th percentiles, the central line represents the median and the whiskers extend to the highest and lowest values no greater than 1.5 × interquartile range).