Extended Data Fig. 3: Relationship between organ-specific toxicity development and HR for death. | Nature Medicine

Extended Data Fig. 3: Relationship between organ-specific toxicity development and HR for death.

From: CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade

Extended Data Fig. 3: Relationship between organ-specific toxicity development and HR for death.

(a) Cox proportional hazards analysis of irAEs by grade and by organ specificity demonstrates grade 1-2 irAEs and specifically dermatitis and arthritis bestow reduced risk of death in MM (n = 299, Dermatitis: HRadj = 0.60, CI 0.41:0.88, P = 0.0088; Arthritis: HRadj = 0.46, CI 0.22:0.96, P = 0.039; Wald test). (b) Cumulative incidence of grade 1-2 irAEs according to CMV status in melanoma (n = 161 CMV-, n = 147 CMV+; P = 0.99, two-sided log-rank test). (c) Cumulative incidence of grade 3+ irAEs is significantly lower in CMV+ patients once restricting to cICB treatment (n = 115 CMV-, n = 78 CMV+; P = 0.0061, two-sided log-rank test).

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