Extended Data Fig. 5: External validation of the streamlined meta-prediction. | Nature Medicine

Extended Data Fig. 5: External validation of the streamlined meta-prediction.

From: Meta-prediction of coronary artery disease risk

Extended Data Fig. 5

Comparative test accuracy for the streamlined meta-prediction model in UKBB (AUROC = 0.81) versus AoU external validation with bootstrapping 95% confidence interval (CI) as the shaded part. a. Tested on the larger AoU validation cohort (AUROC = 0.81), further stratified by self-reported European (EUR), Africna (AFR) and Hispanic (HIS) groups; AoU-EHR (AUROC = 0.81), AoU-AFR (AUROC = 0.79), and AoU-HIS (AUROC = 0.84) respectively. b. And tested in the AoU sub-cohort with complete phenotypes (AUROC = 0.78). Additional conditions tested in AoU include PCE (AUC = 0.72), QRISK3 (AUC = 0.73), and PREVENT (AUC = 0.73). Abbreviations: AoU: All of Us research program; AUC: area under curve; UKBB: UK Biobank.

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