Extended Data Fig. 8: Feature importance and SHAP summary for 10-year prospective CAD risk prediction of generalizable genetic model in the UK Biobank.

This composite figure provides two views of the importance of the final 50 features used in prospective 10-year CAD meta-prediction of generalizable genetic model for the incident CAD cohort (n = 33,419). The left panel displays a bar plot ranking the features in order of importance as quantified by the mean absolute SHAP value. The length of each bar represents the magnitude of a feature’s importance. The right panel presents a SHAP summary plot with each point representing the feature’s SHAP value at an individual level. Color coding represents the feature value (red for high, blue for low). Positive values correspond to the prediction contribution to the positive class, and negative values correspond to the prediction contribution to the negative class. Abbreviations: Dx: Diagnosis; MUF: modifiable and unmodifiable factors; UF: unmodifiable factors.