Fig. 3: Nonsynonymous variants in post-treatment isolate genomes.
a–c, Circular plots showing the distribution of variants in the post-treatment PsA isolate genomes of patient 1 (a), patient 4 (b) and patient 7 (c). Concentric circles represent single isolate genomes. Gray lines represent nonconservative variants that appear in coding sequences in one or more post-treatment isolates but are absent from all pre-treatment isolates. Orange lines represent nonconservative variants (nonsynonymous polymorphisms and frameshifts) coincident with genes expected to be under selection by the phage used in treatment. Labeled, colored arrows indicate the positions and functional categories of these genes. Vertical black lines represent the genome start in the PAO1 reference against which variants were called.
