Fig. 5: Cases averted by vaccination per 1,000 vaccinated children.
From: Efficacy, public health impact and optimal use of the Takeda dengue vaccine
Absolute number of symptomatic cases and hospitalizations averted over 10 years post-second dose in the first vaccinated cohort of 6-year-olds per 1,000 fully vaccinated persons by transmission setting, expressed as the average seroprevalence in 9-year-olds, assuming model VS_D15 (efficacy against disease decaying for 15 years post-vaccination), the Brazilian demography and that 9% of symptomatic cases are hospitalized. a, Cases averted in the entire vaccinated cohort (all; blue), and among the baseline seropositive (green) and baseline seronegative (pink) vaccinees. b, Cases averted by serotype and serostatus. The bars represent the mean, and the error bars represent the overall uncertainty (95%CrI) derived from n = 10,000 simulations (that is, 200 posterior distribution samples × 50 stochastic simulations per sample, see Methods for details).
