Fig. 5: Mean Glx/tNAA change from baseline across ketamine-infusion blocks by sex.

Mean Glx/tNAA change across six infusion blocks relative to the preinfusion baseline, shown separately for placebo and naltrexone pretreatment conditions, split by sex. Females, n = 11 and males, n = 13, with complete MRS data passing quality control. Error bars ± standard errors.