Extended Data Fig. 4: Distributional shifts of ancestry-specific scores before and after ancestry-calibration.
From: Polygenic prediction of body mass index and obesity through the life course and across ancestries
Distributional shifts of ancestry-specific scores which are linearly combined to create PGSLC, across UK Biobank-tuning and BioMe-validation populations, before (top) and after (bottom) ancestry–calibration using 1000 Genomes reference data (Methods). Each plot shows a single ancestry-specific score, with separate lines showing the distribution across ancestries. For these plots, each score was standardised to mean zero and variance one once across all participants of a given study.
