Extended Data Fig. 4: rRFS and OS supervised by prior median 12.75 T cell fold change.
a, OS defined as the time from first vaccine dose until death from any cause and b, radiographic RFS defined as the time from first vaccine dose until confirmed radiographic progression according to iRECIST criteria or death in n = 25 patients. If subsequent therapy was given, radiographic RFS was censored at the date of the most recent radiographic scan before the date of subsequent therapy, the data cutoff or the date of death. Patients were stratified by mKRAS-specific T cell response fold change from baseline at the previously determined median of 12.75. Patients at or above versus below median were compared for a (OS) and b (radiographic RFS). n indicates individual patients. HR indicates hazard ratio with 95% CI. P values calculated using two-tailed log-rank test.
