Extended Data Fig. 1: Individual longitudinal Aβ, tau, PACC5 and CDR-SOB trajectories.
From: Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease
Individual trajectories of (a) global Aβ, (b) inferior temporal cortex (ITC) tau, (c) Preclinical Alzheimer’s Cognitive Composite-5 (PACC5) scores, and d) Clinical Dementia Rating Sum of Boxes (CDR-SOB) scores from all participants are shown without adjustment for any covariates. To allow clear visualization of the individual trajectories, participants were plotted according to high versus low baseline Aβ burden in columns and physical activity (mean steps per day) in rows, defined by above and below the median values. The trajectories are color coded by baseline Aβ burden according to the color bar, with each line representing one participant. The number of participants represented in each facet is provided for reference. The time of baseline PiB PET was used as the study baseline (time = 0). Timing of the first tau PET scan varied across participants (2.2 ± 1.5 years), as tau PET was introduced mid-study when it became available. Aβ = beta-amyloid; DVR = distribution volume ratio; PVC = partial volume correction; PiB = Pittsburgh compound-B; SUVR = standardized uptake value ratio.
