Table 1 Participant characteristics
From: Physical activity as a modifiable risk factor in preclinical Alzheimer’s disease
All participants n = 296 | Longitudinal PiB subgroup n = 241 | Longitudinal tau subgroup n = 172 | |
|---|---|---|---|
Age at baseline, years, mean (s.d.) | 72.3 (7.2) | 72.0 (7.5) | 70.9 (7.5) |
Female, n (%) | 175 (59) | 143 (59) | 100 (58) |
Education, years, mean (s.d.) | 15.8 (3.0) | 16.0 (3.0) | 16.1 (2.9) |
APOE ε4 carriers, n (%) | 81 (28) | 66 (28) | 48 (28) |
Mean steps per day (s.d.) | 5,719 (2,954) | 5,762 (2,961) | 5,888 (2,870) |
Baseline PiB PET FLR DVR, PVC, mean (s.d.) | 1.38 (0.4) | 1.37 (0.4) | 1.35 (0.4) |
Baseline Aβ positive, n (%) | 88 (30) | 67 (28) | 44 (26) |
Baseline cortical gray matter volume, mm3, mean (s.d.) | 420,306 (42,135) | 421,218 (42,783) | 424,958 (44,209) |
Baseline ICV-adjusted hippocampal volume, mm3, mean (s.d.) | 7,501 (739) | 7,496 (748) | 7,538 (756) |
Baseline PACC5 z-score, mean (s.d.) | −0.6 (1.5) | −0.6 (1.6) | −0.5 (1.6) |
No. of longitudinal PACC assessments, median (IQR; range) | 9 (6–11; 2–14) | 9 (7–11; 4–14) | 10 (8–12; 4–14) |
Duration of cognitive follow-up, years, median (IQR; range) | 9.2 (5.3–11.8; 0.9–14.2) | 10.4 (7.0–12.2; 2.8–14.2) | 11.0 (8.1–12.7; 3.4–14.2) |
No. of longitudinal PiB PET scans, median (IQR; range) | – | 3 (2–4; 2–6) | – |
Duration of PiB PET follow-up, years, median (IQR; range) | – | 5.3 (3.3–8.0; 1.5–13.3) | – |
Baseline ITC tau PET SUVR, PVC, mean (s.d.) | – | – | 1.46 (0.2) |
No. of longitudinal tau PET scans, median (IQR; range) | – | – | 3 (2–3; 2–5) |
Duration of tau PET follow-up, years, median (IQR; range) | – | – | 5.0 (3.0–5.5; 1.3–10.5) |
Time between baseline and first tau PET, years, mean (s.d.) | – | – | 2.2 (1.5) |
