Extended Data Fig. 4
From: Cardiotropic AAV gene therapy for heart failure: a phase 1 trial
T-cell responses in (A) Cohort 1 and (B) Cohort 2 assessed by IFN-γ ELISpot assay. (C) Example of patient in Cohort 1 that experienced an increase in capsid-specific IFN-γ ELISpot followed by transient elevations in ALT and AST. (D) Example of patient in Cohort 1 with detectable IFN-γ ELISpot responses whose ALT and AST values remained within normal range. For C and D, bars represent ELISpot responses directed to the capsid in blue and to I-1c in black overlayed with lines representing ALT in orange and AST in purple. Dashed lines indicate ULN for ALT (orange) and AST (purple). ALT, alanine aminotransferase; AST, aspartate aminotransferase; SFU, spot-forming units; ULN, upper limit of normal.
