Table 1 Demographic and clinical characteristics of the patients
From: Anti-inflammatory therapy with low-dose IL-2 in acute coronary syndromes: a randomized phase 2 trial
Characteristic | Placebo (n = 31) | Low-dose IL-2 (n = 32) |
|---|---|---|
Median age (range), years | 55 (39–75) | 56.5 (34–73) |
Sex, no. (%) | ||
Female | 7 (23) | 3 (9) |
Male | 24 (77) | 29 (91) |
BMI, kg m−2 (mean ± s.d.) | 29.6 ± 5.8 | 29.8 ± 5.7 |
Ethnicity, no. (%) | ||
White | 30 (97) | 27 (84) |
Asian | 1 (3) | 3 (9) |
Black | 0 (0) | 0 (0) |
Mixed | 0 (0) | 1 (3) |
Other | 0 (0) | 1 (3) |
Diagnosis at admission, no. (%) | ||
Unstable angina | 0 (0) | 2 (6) |
NSTEMI | 15 (48) | 11(34) |
STEMI | 16 (52) | 19 (59) |
Median hsCRP level, mg l−1 (interquartile range) | 10.1 (5.0–29.1) | 8.4 (4.4–19.2) |
Median high-sensitivity troponin I at the first dosing visit (interquartile range), ng l−1 (range) (reference range 0–54 ng l−1) | 59 (20–346) | 67 (28–305) |
Median low-density lipoprotein–cholesterol level, mmol l−1 (interquartile range) | 1.8 (1.40–2.70) | 2.10 (1.68–2.40) |
GRACE score at admission, mean ± s.d. | 96.1 ± 19 | 95.4 ± 25 |
Cardiovascular history, no. (%) | ||
Hypertension | 29 (94) | 32 (100) |
Hypercholesterolemia | 29 (94) | 32 (100) |
Previous angioplasty | 2 (6) | 5 (16) |
Stroke | 0 (0) | 2 (6) |
Type 2 diabetes | 0 (0) | 2 (6) |
Medication history, no. (%) | ||
Aspirin | 31 (100) | 32 (100) |
Clopidogrel or ticagrelor | 31 (100) | 32 (100) |
Statin | 31 (100) | 31 (97) |
β-Blocker | 30 (97) | 28 (88) |
Renin–angiotensin inhibitor | 30 (97) | 29 (91) |
Smoking status, no. (%) | ||
Never smoked | 12 (39) | 12 (38) |
Current smoker | 12 (39) | 10 (31) |
Previous smoker | 7 (22) | 10 (31) |
Baseline arterial inflammation, mean TBRmax | 2.39 ± 0.28 | 2.26 ± 0.27 |
Treatment given for index ACS admission, no. (%) | ||
Percutaneous coronary angioplasty | 31 (100) | 30 (94) |
Medical management | 0 (0) | 2 (6) |
Culprit vessel leading to index ACS admission, no. of patients (%) | ||
Left anterior descending artery | 16 (52) | 17 (53) |
Left circumflex artery | 6 (19) | 6 (19) |
Right coronary artery | 9 (29) | 9 (28) |
