Fig. 2: asF of PGx variants in the MXB.
From: Clinical genetic variation across Hispanic populations in the Mexican Biobank
a, Comparison of asF for 58 high-evidence SNPs associated with drug response, curated from the PharmGKB database. Allele frequencies were calculated exclusively within chromosomal segments assigned to either Indigenous or European ancestry. Gray points represent state-level asF estimates, while colored points indicate the national average for each ancestry. Distance from the diagonal reflects the degree of ancestry enrichment. SNPs are color-coded by level of evidence, and icons indicate associated clinical phenotypes for selected variants. b, Geographic distribution of allele frequencies for SNP rs2242480-T, illustrating a regional gradient with higher frequencies in southeastern Mexico. c, Proportion of Indigenous ancestry among individuals with different genotypes at rs2242480, showing increased Indigenous ancestry in individuals carrying the C allele. The centerline represents the median, the box bounds correspond to the 25th and 75th percentiles, and whiskers extend to the most extreme values within 1.5× the interquartile range (n = 6,011, t test two-sided). d,e, Distribution of asF for rs2242480-T, showing enrichment of the C allele within Indigenous chromosomal segments (e) compared to European ones (d), highlighting population-level genetic differentiation relevant to PGxs. Images in b, d and e are adapted from ref. 38, used under a free use license.
