Fig. 5: MexVar is an interactive platform for exploring ancestry- and geography-informed allele frequencies in the MXB.
From: Clinical genetic variation across Hispanic populations in the Mexican Biobank
MexVar integrates genomic and ancestry data from 6,011 individuals in the MXB, using continental reference panels to perform local ancestry inference. A curated set of 42,769 unique SNPs, compiled from ClinVar, GWAS Catalog, PharmGKB and OMIM, was analyzed. Although 44,305 total entries were included across databases, some SNPs appear in more than one database. The pipeline includes local ancestry inferences, ancestry masking and the computation of asF. MexVar is built on a user-friendly Shiny interface that enables interactive visualization of geographic and ancestry-specific variant distributions across Mexico. The platform supports the interpretation of clinically relevant genetic variation in the context of population structure, advancing equitable precision medicine.
