Extended Data Fig. 2: Allele frequency landscape of clinically relevant variants in the Mexican Biobank.
From: Clinical genetic variation across Hispanic populations in the Mexican Biobank
(a) Geographic map of Mexico showing the sampling locations of the 6,011 individuals in the MXB. Each point represents a sample, with shape indicating urban (triangle) or rural (circle) origin. States are color-coded by average proportion of Indigenous genetic ancestry. Image in panel a is reproduced with permission from Valle-Jones D. (ref. 38), used under a free use license. (b) Pairwise Fst heatmap showing genetic differentiation between Mexican states based only on clinically relevant genetic variants. (c) Distribution of minor allele frequencies (MAFs) for clinically relevant SNPs in the MXB dataset, grouped by source database (ClinVar, GWAS Catalog, PharmGKB, OMIM).
