Extended Data Fig. 3: Association with T2D risk for complex lipids and fatty acids by carbon chain length and double-bond numbers.
For complex lipid metabolites and fatty acids, we tested the correlation between their association coefficients (with T2D, from Model 2) with carbon chain length and double-bond numbers. Correlations with P < 0.05 were demonstrated, including for free fatty acids (A), cholesterol esters (B), diacylglycerols (C), triacylglycerols (D), phosphatidylcholines (E), plasmalogens (F), and sphingomyelins (G). In each sub-figure, x- and y-axis each represents carbon chain length and double-bond numbers, respectively; and the z-axis represents the natural log-transformed relative risk (RR) for T2D per standard deviation increase in the levels of metabolites. Significant correlations and P values were highlighted in red ( + and – indicate positive and negative correlations, respectively).
