Extended Data Fig. 6: TLC-2716 maintains lipid homeostasis in a humanized liver murine model. | Nature Medicine

Extended Data Fig. 6: TLC-2716 maintains lipid homeostasis in a humanized liver murine model.

From: An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial

Extended Data Fig. 6: TLC-2716 maintains lipid homeostasis in a humanized liver murine model.

(a) Schematic for the evaluation of TLC-2716 in humanized liver chimeric PXB® mice. (b, c) Liver triglyceride (TG) content (b) and levels of liver transcripts involved in lipid synthesis and metabolism (c) in humanized liver chimeric PXB mice treated with TLC-2716 (1 mg/kg, once daily by oral gavage) for 8 days. n = 5/group. P values were calculated by two-tailed Mann-Whitney U test and adjusted by Benjamini-Hochberg (BH) adjustment. Box plots indicate the median (center line), interquartile range (IQR) (box bounds, 25th and 75th percentiles) and smallest and largest values within 1.5× IQR (whiskers) (b-c).

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