Extended Data Fig. 7: Effect of TLC-2716 on plasma lipids and hepatic safety in mice and in cynomolgus monkeys.
(a-b) Plasma TG (a) and TC (b) in a GLP toxicology study in cynomolgus monkeys treated with vehicle (n = 5/sex) or TLC-2716 1 mg/kg (n = 2 for male, n = 3 for female), 5 mg/kg (n = 5/sex), and 15 mg/kg (n = 5/sex) once daily by oral gavage for 28 days. (c-f) Plasma TG (c), TC (d), ALT (e), and the ratio between ALT and AST (f) in CD-1 mice treated with 26 weeks of vehicle or TLC-2716 (15, 60, and 120 mg/kg) once daily by oral gavage. n = 10/group. P values were calculated by two-tailed Mann-Whitney U test and adjusted by BH adjustment. Box plots indicate the median (center line), interquartile range (IQR) (box bounds, 25th and 75th percentiles) and smallest and largest values within 1.5× IQR (whiskers) (a-f).
