Extended Data Fig. 10: TLC-2716 does not exhibit pro-inflammatory or pro-fibrotic effects in steatotic human liver organoids (sHLOs).
(a-e) Normalized gene expression of pro-inflammatory or pro-fibrotic genes in two subtypes of sHLOs, defined by the presence of variants in GCKR (CC vs TT). n = 3 samples per group. P values were calculated by two-tailed Student’s t-test and BH-adjusted P values were indicated as follows: ns (not significant) BH-adjusted P value > 0.05. Box plots indicating the median (center line), interquartile range (IQR) (box bounds, 25th and 75th percentiles) and smallest and largest values within 1.5× IQR (whiskers) (a-e).
