Fig. 5: Evaluation of the effect of TLC-2716 on lipid metabolism in humans.
a–k, Dot plots showing the therapeutic effect of 14 days of treatment with TLC-2716 at 0.5, 2, 6 or 12 mg on TG (a), RC (b), TC (c), non-HDL-C (d), LDL-C (e), the number of total LDL particles (f) and small LDL particles (g), ApoB (h), HDL-C (i), TG/HDL-C ratio (j) and Lipo-IR (k). The significance of comparisons between day 14 and day 1 within the same dose group was calculated by two-tailed Wilcoxon signed-rank test and adjusted by the BH method, while the significance of relative (%) changes of each parameter following 14 days of treatment compared with placebo calculated by [(day 14 – day 1) / day 1] was calculated by two-tailed Mann–Whitney U-test and adjusted by the BH method.
