Extended Data Fig. 8: SGBs loss modulates tryptophan levels and the plasma cytokine profile. | Nature Medicine

Extended Data Fig. 8: SGBs loss modulates tryptophan levels and the plasma cytokine profile.

From: Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial

Extended Data Fig. 8

A. Tryptophan metabolite according to SGBs loss calculated from the patient’s baseline (n = 46 samples from n = 23 patients), p-value calculated by Spearman r correlation (two-sided) B. Olink proteomics assay UMAP representation in patients with high percentage of bacterial loss according to baseline, defined by the median, compared to low percentage of bacterial loss according to baseline, p-value calculated by one-way ANOVA (two-sided) C. Volcano plot of significantly enriched proteins post-FMT compared to baseline (n = 35 samples from n = 15 patients for patients with high loss and n = 37 samples from n = 16 patients for patients with low loss), p-value calculated by Welch 2-sample t-test (two-sided), corrected for multiple testing by the Benjamini-Hochberg method.

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