Extended Data Fig. 4: Species and strain-level dynamics and association with response. | Nature Medicine

Extended Data Fig. 4: Species and strain-level dynamics and association with response.

From: Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial

Extended Data Fig. 4

A. Response status according to donor cluster for NSCLC and melanoma. Group differences were assessed using Fisher test (two-sided). B. Alpha diversity measured by the Shannon index comparing donors, responders, and non-responders at baseline versus post-FMT (n = 180 samples from n = 39 patients and 9 donors). C. Bray-Curtis dissimilarity to donor fold change over time (n = 182 samples from n = 37 patients) and D. absolute strains shared with the donor for NSCLC and melanoma cohorts in non-responders vs. responders (n = 156 samples from n = 34 patients), data are presented as mean values ± SD, for strain-sharing analysis only samples which successfully processed through the StrainPhlAn4 pipeline. E. Visualisation of overlap between enriched species in responders post-FMT from LEfSe analysis. For box plots (B), the center line represents the median, box bounds represent the interquartile range (IQR), whiskers extend to 1.5 x IQR, and each dot represents an individual patient sample. R; responder. NR; non-responder. P-values for panels B–D are pair-wise comparison using Wilcoxon test (two-sided).

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