Extended Data Fig. 5: Key cytokine levels in serum samples collected at different time points.
From: Anti-CD19 CAR T cells for pediatric patients with treatment-refractory autoimmune diseases
a, Box plot representing the peak levels of IFN-γ, IL-10, IL-6 and TNF. The higher levels of IL-6 refer to patient JDM-OPBG004 and cSLE-FAU001. Individual values derived from individual patients are reported, with boxes representing first quartile, median and forth quartile distribution. Boundaries of lower and upper whiskers show minimum and maximum values. Grade 1 cytokine release syndrome occurred in both patients, while grade 1 immune effector cell-associated neurotoxicity syndrome was experienced by JDM-OPBG004. Tocilizumab was administered to cSLE-FAU001 on day 5. Highest levels of IFN-γ, IL-10 and TNF have been shown in patient JDM-OPBG004. b, Evolution of serum levels of IL-6, IFN-γ, TNF and IL-10 in all patients infused with zorpocabtagene-autoleucel. Serum IL-10 levels were systematically studied only in patients treated at OPBG.
