Fig. 3: Genic burden of PTVs in EUR versus AMR ancestries as a function of gene constraint. | Nature Medicine

Fig. 3: Genic burden of PTVs in EUR versus AMR ancestries as a function of gene constraint.

From: Deleterious coding variation associated with autism is shared across ancestries

Fig. 3: Genic burden of PTVs in EUR versus AMR ancestries as a function of gene constraint.

The sum of observed PTVs is plotted for non-Finnish European (NFE; n = 56,885) and AMR (n = 17,296) populations in gnomAD version 2.1.1, scaled to population size and total coding sequence length for each gnomAD LOEUF decile. LOEUF deciles reflect gene constraint, with lower deciles indicating more constrained genes.

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