Table 2 Antibiotic use in the population-based cohorts by period before fecal sampling

From: Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals

 

SCAPIS

SIMPLER

MOS

Period

<1 year

1–4 years

4–8 years

<1 year

1–4 years

4–8 years

<1 year

1–4 years

4–8 years

Penicillin V

559 (6.6%)

1,501 (17.7%)

2,124 (25%)

272 (5.7%)

915 (19.1%)

1,266 (26.5%)

109 (6.4%)

332 (19.4%)

482 (28.2%)

Tetracyclines

287 (3.4%)

858 (10.1%)

1,405 (16.6%)

146 (3.1%)

420 (8.8%)

704 (14.7%)

60 (3.5%)

189 (11.1%)

265 (15.5%)

Penicillins ES

301 (3.5%)

824 (9.7%)

1,013 (11.9%)

201 (4.2%)

559 (11.7%)

615 (12.9%)

48 (2.8%)

149 (8.7%)

209 (12.2%)

Flucloxacillin

166 (2%)

570 (6.7%)

732 (8.6%)

120 (2.5%)

349 (7.3%)

428 (8.9%)

28 (1.6%)

104 (6.1%)

142 (8.3%)

Fluoroquinolones

136 (1.6%)

384 (4.5%)

506 (6%)

126 (2.6%)

361 (7.5%)

480 (10%)

12 (0.7%)

56 (3.3%)

69 (4%)

Nitrofurantoin

138 (1.6%)

374 (4.4%)

331 (3.9%)

113 (2.4%)

288 (6%)

272 (5.7%)

23 (1.3%)

87 (5.1%)

61 (3.6%)

Clindamycin

104 (1.2%)

298 (3.5%)

387 (4.6%)

37 (0.8%)

131 (2.7%)

160 (3.3%)

20 (1.2%)

64 (3.7%)

83 (4.9%)

Sulfamethoxazole-trimethoprim

38 (0.4%)

142 (1.7%)

209 (2.5%)

46 (1%)

132 (2.8%)

196 (4.1%)

2 (0.1%)

27 (1.6%)

52 (3%)

Cephalosporins

46 (0.5%)

142 (1.7%)

247 (2.9%)

19 (0.4%)

52 (1.1%)

119 (2.5%)

16 (0.9%)

45 (2.6%)

77 (4.5%)

Macrolides

42 (0.5%)

132 (1.6%)

243 (2.9%)

12 (0.3%)

51 (1.1%)

81 (1.7%)

15 (0.9%)

42 (2.5%)

65 (3.8%)

Amoxicillin-clavulanic acid

33 (0.4%)

76 (0.9%)

111 (1.3%)

9 (0.2%)

39 (0.8%)

60 (1.3%)

2 (0.1%)

9 (0.5%)

17 (1%)

  1. Number of individuals who had at least one antibiotic course in the 8 years before fecal sampling in the three cohorts, in each time period. <1 year: <1 year before fecal sampling (1-year period); 1–4 years: ≥1 and <4 years before fecal sampling (3-year period); 4–8 years: ≥4 and <8 years before fecal sampling (4-year period). Penicillins ES, extended-spectrum penicillins.