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An atlas to navigate environmental factors and health

We have systematically mapped the exposome onto health and disease risk to replace pervasive fragmented research. Although exposure associations are modest, these reproducible patterns reflect how our surroundings can affect our bodies and collectively shape our health. Our atlas provides a blueprint for integrating and evaluating environmental factors into precision medicine.

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Fig. 1: A schematic for a new paradigm for exposomic discovery.

References

  1. Patel, C. J. & Ioannidis, J. P. A. Studying the elusive environment in large scale. JAMA 311, 2173–2174 (2014). An article that presents a new paradigm for discovery for environmental health.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Lakhani, C. M. et al. Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes. Nat. Genet. 51, 327–334 (2019). This paper reports the total genetic and shared environmental contribution using twin data.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Argentieri, M. A. et al. Integrating the environmental and genetic architectures of aging and mortality. Nat. Med. 31, 1016–1025 (2025). An article that presents the elusive environmental variation in common diseases benchmarked against genetic risk scores.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Diao, J. A. et al. Projected changes in statin and antihypertensive therapy eligibility with the AHA PREVENT cardiovascular risk equations. JAMA 332, 989–1000 (2024). An article that presents differences in cardiovascular screening techniques that seek to incorporate environmental risk factors.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Vermeulen, R., Schymanski, E. L., Barabási, A.-L. & Miller, G. W. The exposome and health: Where chemistry meets biology. Science 367, 392–396 (2020). An article that presents how to assess external chemicals in humans.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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This is a summary of: Patel, C. J. et al. An atlas of exposome–phenome associations in health and disease risk. Nat. Med. https://doi.org/10.1038/s41591-026-04266-0 (2026).

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An atlas to navigate environmental factors and health. Nat Med (2026). https://doi.org/10.1038/s41591-026-04286-w

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