Table 1 EEG analysis of patients with KT777 treatment

From: Antisense oligonucleotide-mediated knockdown therapy in two infants with severe KCNT1 epileptic encephalopathy

EEG date

Seizures (normalized to 24 h)

Duration

Semiologies

Patient 1

Week 0

19

15–60 s

Focal tonic

Week 5

17

15–90 s

Focal tonic, ± progression into unilateral clonic

Week 23

18

1–64 s (tonic), <1 s (myoclonic)

Majority focal tonic (17), minority myoclonic (1)

Week 29

33

10–30 s (tonic), <1 s (myoclonic)

Majority focal tonic (30), minority myoclonic (3)

Week 36

30

10–30 s (tonic), <1 s (myoclonic)

Majority myoclonic, minority brief focal tonica

Week 45

20

10–30 s (tonic), <1 s (myoclonic)

Majority brief focal tonic (19), minority myoclonic (1)

Patient 2

Week 0

18

6–10 s

Focal tonic

Week 4

22

8–15 s

Focal tonic

Week 6

10

9–22 s

Focal tonic

Week 14

4

12–40 s

Focal tonic

  1. aSeizure count by semiology for patient 1 week 36 is not available.