Fig. 1: Exposome-related methylation risk scores show differences between early- and late-onset CRC patients. | Nature Medicine

Fig. 1: Exposome-related methylation risk scores show differences between early- and late-onset CRC patients.

From: Epigenetic fingerprints link early-onset colon and rectal cancer to pesticide exposure

Fig. 1: Exposome-related methylation risk scores show differences between early- and late-onset CRC patients.The alternative text for this image may have been generated using AI.

Summary overview of the association between the 63 exposome-related MRSs across 29 exposome traits (y axis) and five selection thresholds (x axis, as applied in the original EWAS), comparing early-onset (age <50 years) to late-onset (age ≥70 years, reference) cancer using sex-adjusted logistic regression. The discovery phase (left panel) was conducted in TCGA-COAD (31 early-onset versus 100 late-onset colon cancer). The replication phase (right panel) shows meta-analysis results from nine cohorts (E-MTAB-3027, E-MTAB-7036, GSE199057, GSE131013, GSE42752, TCGA-READ, GSE39958, GSE101764 and GSE77954), including 83 EOCRC and 272 LOCRC patients. The selection thresholds (x axis) indicate the significance threshold in the original EWAS used for CpG selection, namely P < 1.2 × 10−7 (GW), P < 1.0 × 10−5 (P1E5) and FDRs of <0.1 (F01), <0.05 (F005) and <00.1 (F001). The presence of CpGs across the five selection thresholds varies, with unavailable data indicated in white (NA), and nonsignificant findings in light gray.

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