Extended Data Fig. 3: Gene carrier frequency (GCF) comparison across gnomAD 4.0 continental populations and the HKGP Chinese cohort.
From: Population-scale genomic medicine with the Hong Kong Genome Project
This figure shows the comparison of GCF for ACMG and non-ACMG carrier screening (CS) genes in the HKGP Chinese cohort versus other continental populations from gnomAD 4.0 (non-Finnish Europeans, East Asians, and Africans). Colours and shapes indicate both the ACMG tier classification of genes and the pairwise GCF comparisons between populations, consistent with Fig. 3d and the ACMG categorization. Subfigures illustrate specific comparisons as follows: a, HKGP Chinese vs. non-Finnish Europeans. b, HKGP Chinese vs. East Asians. c, non-Finnish Europeans vs. East Asians. d, non-Finnish Europeans vs. Africans. GCF, gene carrier frequency.
