Extended Data Fig. 6: 3D structures of Yeast nuclei_hAZFa compared with Yeast_ hAZFa.
From: De novo assembly and delivery of synthetic megabase-scale human DNA into mouse early embryos
a, 3D formation shows interactions of hAZFa and endogenous chromosomes in isolated nuclei. b, Z-score difference contact heatmap shows a comparison of chromosome interactions of Yeast nuclei_hAZFa and Yeast_hAZFa. Bin length, 10-kb; red and blue show increased and decreased chromatin interactions, respectively. c, Comparison of the centromere relative interaction frequency between isolated yeast nuclei and Yeast_hAZFa. Data are presented as the mean ± s.e. Two-tailed t-tests were used to evaluate differences between groups. (***) P < 0.001.
