Extended Data Fig. 7: H3K9me3 signals of hAZFa, and DNA methylation of hAZFa and data-carrying BAC in mouse early embryos. | Nature Methods

Extended Data Fig. 7: H3K9me3 signals of hAZFa, and DNA methylation of hAZFa and data-carrying BAC in mouse early embryos.

From: De novo assembly and delivery of synthetic megabase-scale human DNA into mouse early embryos

Extended Data Fig. 7: H3K9me3 signals of hAZFa, and DNA methylation of hAZFa and data-carrying BAC in mouse early embryos.The alternative text for this image may have been generated using AI.

a, Genome browser view showing that de novo H3K9me3 of hAZFa in mouse 2-cell embryos compared with AZFa in human 4-cell and 8-cell embryos. b, The random snapshot from UCSC Genome Browser showing the H3K9me3 profile of our injected mouse early two-cell embryos performed by CUT&Tag, in comparison to the published H3K9me3 Chip-seq data from wild-type mouse early 2-cell embryos. c, The DNA methylation levels of hAZFa and yeast genome in mouse one-cell embryos compared with those in yeast. d, The DNA methylation level of data-carrying BAC in E. coli and in mouse one-cell embryos.

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