Extended Data Fig. 7: SFRP1 clonal structure would be difficult to detect without high resolution.
From: SpaceBar enables single-cell-resolution clone tracing with imaging-based spatial transcriptomics
A. Expression of SFRP1 in the neighborhood of Clone 31 as depicted in Fig. 2, with grids spaced 55µm apart. B. A series of heatmaps that depict the expression pattern of SFRP1 as well as the distribution of spots that label distinct clones in this area of the tumor section. Clones are depicted as the sum of all transcripts for barcodes assigned to that clone. While only clone 31 has true clonal SFRP1 gene expression from our high-resolution data, all nine depicted clones have significant correlations (p < 0.01) with SFRP1 expression when binned at 55µm resolution.
