Extended Data Fig. 6: Examples of ANNEVO Correcting Erroneous Gene Annotations in Ensembl. | Nature Methods

Extended Data Fig. 6: Examples of ANNEVO Correcting Erroneous Gene Annotations in Ensembl.

From: Highly accurate ab initio gene annotation with ANNEVO

Extended Data Fig. 6: Examples of ANNEVO Correcting Erroneous Gene Annotations in Ensembl.

a, Correction of a gene loss. Ensembl failed to annotate a conserved BUSCO gene at this region. ANNEVO recovered this gene, fully supported by RNA-seq evidence. b, Correction of a premature stop codon. Due to an erroneous splice site, the Ensembl annotation introduced a premature stop codon, resulting in the loss of four downstream exons. ANNEVO recovered this gene, fully supported by RNA-seq evidence. c, Correction of an incorrect start codon. Ensembl missed an upstream exon, leading to an incorrect initiation site. ANNEVO recovered this gene, fully supported by RNA-seq evidence.

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