Extended Data Fig. 4: Head-to-head comparison of SPEND with BM4D and Noise2Void (N2V).
From: FILM: mapping organellar metabolism by mid-infrared photothermal-modulated fluorescence
a, FILM images of lysosomes were acquired with IR at 1711 cm−1 and 1797 cm−1 before and after three denoising algorithms. b, the intensity profiles along the red dotted lines indicated in a. c, compares the raw, uncalibrated FILM spectra before and after three denoising algorithms. d, the quantification of image SNR and spectral SNR before and after three denoising algorithms (n = 13 lysosomes). In d, the boxes show the IQR, the centerlines indicate medians and the lines outside the boxes extend to 1.5 times the IQR. Scale bar: 10 μm.
