Extended Data Fig. 8: Diverse spatiotemporal filtering by GABA signal groups.
(a) Schematic of synaptic transmission from amacrine cell (dark gray) to post-synaptic cell (light gray) during motion stimuli. (b) Spatiotemporal integration model to simulate light-evoked responses in individual GABA signal groups. The spatiotemporal profile of each visual stimulus is convolved with the spatial and temporal receptive field in each response group. (c) G14, G6, and G32 amacrine cell (cyan) and bipolar cell (black) models during motion stimuli of different speeds. (d) Top, modulatory efficacy of bipolar cell response by amacrine cell. Bottom, relationship between motion speed and modulatory efficacy in three example groups (G14, G6, and G32). (e) Matrix of motion speed tuning and modulatory efficacy for 49 groups (left) and matrix sorted by optimal speed (right). (f) Top, clustering based on speed tuning (converted from µm/s to °/s). Bottom, plausible functional relevance for speed tuning. Numbers indicate reference number (in g). (g) References for the plausible range of speed tunings in (f). Wallace et al.61, Martinez-Conde and Macknik62, Michaiel et al.63, Payne and Raymond64, Sakatani and Isa40, Meyer et al.41, Harrod and Baker65, Migliaccio et al.66.
