Extended Data Fig. 6: Top 100 hits in the CASPR-labeled paranode-enriched proteome and MAG-labeled myelin-axon interface proteome in unaffected human brains. | Nature Neuroscience

Extended Data Fig. 6: Top 100 hits in the CASPR-labeled paranode-enriched proteome and MAG-labeled myelin-axon interface proteome in unaffected human brains.

From: Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain

Extended Data Fig. 6

(a) The top 100 proteomic hits identified in the paranode-enriched proteome. Proteins known to be expressed in the paranode are marked with an asterisk (‘*’): SPTAN1123, SPTBN1124,125, CNTN1126,127, CNTNAP135, ANK321,128, NFASC129, and SCN2A130. Proteins known to be expressed in the node of Ranvier and juxtaparanode are marked with a hash (‘#’): TNR1, ACTN4131, SPTBN41, VCAN1, NCAM1132, CNTNAP2129, SPTB133, CNTN21, HAPLN21, NCAN1, EPB41L21. (b) The top 100 proteomic hits identified in the myelin-axon-interface proteome. Proteins known to be expressed at the myelin-axon interface are marked with an asterisk (‘*’): CNP134, CNTN1126,127, CNTNAP135, NFASC129, NCAM1132, MOG134, MAG36,37,38, SEPTIN7135, NRCAM136, CNTN236,37,38, PLP120, CNTNAP21, LGI3137, SEPTIN8138, CADM420,139, ADAM22137, SEPTIN2138,140, SEPTIN4138. Proteins known to be related to myelin or axon are marked with a hash (‘#’): DPYSL2141, INA1142, IGSF8143,144, STX1B145, BIN1146, SNAP25147, NCAM2148, NDRG1149,150, CRMP1151, BCAS1152, KCNAB2153, LGI1154, MAPT155, GPM6A156, CAP1157, PLEKHB1158.

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