Extended Data Fig. 7: Integrative pathway enrichment analysis of paranode and myelin-axon interface proteomes using the ActivePathways method. | Nature Neuroscience

Extended Data Fig. 7: Integrative pathway enrichment analysis of paranode and myelin-axon interface proteomes using the ActivePathways method.

From: Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain

Extended Data Fig. 7: Integrative pathway enrichment analysis of paranode and myelin-axon interface proteomes using the ActivePathways method.

(a-b) The Enrichment Map depicts a network of pathways (FDR < 0.05) where edges connect pathways sharing many genes. Node size reflects the number of genes in each pathway, and node color indicates the dataset contribution (combined AD and control). Theme labels were curated based on the main pathways represented in each subnetwork. Only subnetworks with at least four pathways connected by edges are shown. Grey nodes indicate combined evidence of pathway enrichment in which the respective pathways were detected in the integrative analysis but not detected in either the AD or Control proteomes alone.

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