Extended Data Fig. 1: Data-driven HPC domain annotations derived from spatial clustering (PRECAST kâ=â18) across all nâ=â36 Visium-H&E samples.

Spatial clustering results from PRECAST kâ=â18 were annotated to HPC spatial domains by examining marker gene expression and anatomical location. From the 18 PRECAST clusters we generated 16 spatial domains by merging clusters that were annotated to the same HPC subfields. Spot color indicates the final spatial domain annotation (legend in bottom right). See Supplementary Table 2 for abbreviations. Capture areas are grouped by donor number.