Extended Data Fig. 3: Differentially expressed snRNA-seq genes and correlation with SRT results. | Nature Neuroscience

Extended Data Fig. 3: Differentially expressed snRNA-seq genes and correlation with SRT results.

From: An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus

Extended Data Fig. 3

Dot plots for select differentially expressed genes (y-axis) for n = 60 cell types (x-axis). Dot color indicates the cluster average log2 normalized counts and dot size corresponds to the proportion of cluster nuclei with non-zero expression. Heatmaps are included for (a) glia, (b) retrohippocampus (RHP), (c) amygdala, (d) GABAergic neurons, (e) GABAergic neuron markers with higher expression range (including Cajal–Retzius neurons for RELN expression comparison), (f) hippocampus (HPC), (g) and dentate gyrus granule cells. See Supplementary Table 2 for cluster abbreviations. h, Heatmap of Pearson correlation coefficients (color) showing the relationship between pseudobulk differential expression analysis enrichment model t statistics for the SRT spatial domains (rows) and those of n = 60 snRNAseq clusters (columns).

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