In this issue, Stamenkovic et al. describe deep in vivo imaging of the brain vasculature to document its evolution during aging, which identifies a unique vulnerability at the site of convergence of capillaries toward major veins. They propose that pericyte and capillary instability there cause mild hypoperfusion, ultimately leading to myelin degradation.
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Assali, A., Renier, N. The brain drain puts aging myelin in deep trouble. Nat Neurosci 28, 1814–1815 (2025). https://doi.org/10.1038/s41593-025-02028-8
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DOI: https://doi.org/10.1038/s41593-025-02028-8
