Extended Data Fig. 5: Additional characterization of circadian rhythms in gene expression in microglia. | Nature Neuroscience

Extended Data Fig. 5: Additional characterization of circadian rhythms in gene expression in microglia.

From: A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging

Extended Data Fig. 5

a, Heatmap showing temporally-coordinated gene expression in microglia from WT mice for the proteasome pathway alongside the same genes plotted in APP microglia. b, Heatmap showing temporally-coordinated gene expression in microglia from WT mice for the Alzheimer’s disease pathway alongside the same genes plotted in APP microglia. c, Graph showing the acrophase of rhythmic genes in microglia from WT and APP/PS1 mice. Genes are separated by the KEGG pathway. d, Graphs depicting circadian rhythms in expression of disease-associated microglial (DAM) activation genes. Adjusted P values from RAIN are shown.

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